Acetyl-CoA carboxylase

Other Metabolism Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Cat.No.	Product Name	Information	Product Use Citations
S8893	Firsocostat (GS-0976, ND-630)	Firsocostat (GS-0976, ND-630) is a reversible inhibitor of acetyl CoA carboxylase (ACC) with IC50s of 2.1 nM, 6.1 nM for hACC1 and hACC2, respectively.	Adv Sci (Weinh), 2024, 11(46):e2401311 Nat Commun, 2023, 14(1):1362 Genome Med, 2022, 14(1):67
S6690	TOFA	TOFA is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). Inside the cell, this compound is converted to TOFyl-CoA (5-tetradecyloxy-2-furoyl-CoA), exerting an allosteric inhibition on ACCA. It blocks fatty acid synthesis and induces cell death in a dose-dependent manner.	J Clin Invest, 2025, e190215 J Transl Med, 2025, 23(1):1055 Oncotarget, 2025, 16:532-544
S6672	PF-05175157	PF-05175157 is a broad-spectrum effective ACC inhibitor with IC50 of 27.0 nM, 33.0 nM, 23.5 nM and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively.	Nat Commun, 2025, 16(1):509 Cancer Cell Int, 2023, 23(1):83 Liver Res-Prc, 2023, Volume 7, Issue 2 Pages 124-135
S8377	ND646	ND-646 is an allosteric inhibitor of the ACC (Acetyl-CoA carboxylase) enzymes that prevents ACC subunit dimerisation to suppress fatty acid synthesis with IC50 of 3.5 nM and 4.1 nM for hACC1 and hACC2, respectively.	Cancer Discov, 2023, 13(2):496-515 Cancer Sci, 2023, 114(4):1651-1662
S6753	CP 640186	CP 640186 is an isozyme-nonselective ACC (Acetyl-CoA carboxylase) inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.	Exp Ther Med, 2020, 20(1):521-529 Molecules, 2015, 20(9):16221-34
S5519	4-Methylsalicylic acid	4-Methylsalicylic acid (m-Cresotic acid, 2-Hydroxy-4-methylbenzoic acid, m-Cresotinic acid, 2-Hydroxy-p-toluic acid) is used to inhibit the medium chain acyl-CoA synthetase.
S6145	PF-05221304	PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyses the first committed step in de novo lipogenesis (DNL).
S6112	Oxalacetic acid	Oxalacetic acid (Oxaloacetic acid, 2-Oxosuccinic acid, Ketosuccinic acid) is an intermediate of the citric acid cycle, where it reacts with acetyl-CoA to form citrate, catalysed by citrate synthase. It is also involved in gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, and fatty acid synthesis. Oxaloacetate is also a potent inhibitor of Complex II.