| S5717 |
Acetohexamide
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Acetohexamide is an intermediate-acting, first-generation oral sulfonylurea with hypoglycaemic activity. It exerts the blood-glucose-lowering effects by stimulating the pancreatic beta cells to secrete insulin and by helping the body use insulin efficiently.
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| S4299 |
Dicoumarol
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Dicoumarol is a competitive NADPH quinone oxidoreductase (NQO1) inhibitor, and used as an anticoagulant by interfering with the Metabolism of vitamin K.
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Adv Sci (Weinh), 2025, 12(7):e2411538
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Redox Biol, 2024, 75:103292
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Acta Pharmacol Sin, 2023, 1-13.
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| S1907 |
Metronidazole
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Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa.
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Dis Model Mech, 2024, 17(10)dmm050900
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Microorganisms, 2022, 10(7)1421
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Elife, 2021, 10e69795
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| S5703 |
Carvedilol Phosphate
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Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity.
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Res Pharm Sci, 2016, 11(5):419-427
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Res Pharm Sci, 2015, 10(5):388-96
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| S9617 |
G6PDi-1
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G6PDi-1 is an effective inhibitor of glucose-6-phosphate dehydrogenase (G6PD). This compound depletes NADPH and decreases inflammatory cytokine production.
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EMBO J, 2023, e110620.
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| S6749 |
ASP-9521
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ASP-9521 is a selective, orally bioavailable inhibitor of 17beta-hydroxysteroid dehydrogenase type 5 (17β-HSD5), also known as aldo-keto reductase family 1 member C3 (AKR1C3).
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| S0764 |
AKR1C1-IN-1
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AKR1C1-IN-1 is a potent and selective inhibitor of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with Ki of 4 nM, 87 nM, 4.2 μM and 18.2 μM for AKR1C1, AKR1C2, AKR1C3 and AKR1C4, respectively.
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| S0468New |
AKR1C3-IN-1
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AKR1C3-IN-1 is a highly potent inhibitor of aldo-keto reductaseAKR1C3 with an IC50 of 13 nM. It can be used in research targeting both breast and prostate cancer.
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