Opioid Receptor Inhibitors

Cat.No.	Product Name	Information
E2868	Naloxegol Oxalate	Naloxegol oxalate (NKTR-118 oxalate) is a μ-Opioid Receptor antagonist with a Ki of 33.8 nM. Naloxegol oxalate inhibits opioid binding in μ-Opioid Receptors in the gastrointestinal tract and is effective for alleviating opioid-induced constipation.
S4588	Docusate Sodium	Docusate Sodium (Aerosol OT, Bis(2-ethylhexyl) sulfosuccinate sodium salt, Constonate) is a laxative used to treat constipation. For constipation due to the use of opiates it may be used with a stimulant laxative, and can be taken by mouth or rectally.
E2880	methylnaltrexone bromide	methylnaltrexone bromide is an antagonist of µ-Opioid Receptor that reduces the viability of lung cancer cells by inhibiting Src activation.
E7162	CTAP	CTAP is a potent, highly selective, and blood–brain barrier penetrant antagonist of μ opioid receptor with an IC50 of 3.5 nM. It displays over 1200-fold selectivity over δ opioid and somatostatin receptors. It exhibits anti-dyskinetic potential and can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction.
S2085	Trimebutine	Trimebutine (Mebutin) is an agonist of peripheral mu, kappa and delta opiate receptors, used as a spasmolytic agent for the treatment of both acute and chronic abdominal pain.