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cAMP Inhibitors

Cat.No. Product Name Information Product Use Citations Product Validations
S0837 HJC0197 HJC0197 is a selective Epac 1/2 dual antagonist with an IC50 of 5.9 μM for Epac2.
S6478 Fipexide hydrochloride Fipexide hydrochloride is a psychoactive drug of the piperazine class.
S0451 ST034307 ST034307 is a potent and selective inhibitor of adenylyl cyclase 1 (AC1) with an IC50 of 2.3 μM.
E6044 3-O-Methylquercetin 3-O-Methylquercetin is a flavone isolated from Rhamnus nakaharai Hayata (Rhamnaceae), an inhibitor of cAMP and cGMP-phosphodiesterases (PDE) with an IC50 of 13.8 μM and 14.3 μM respectively. It also inhibits β-secretase with an IC50 of 6.5 μM. It exhibits antiviral activity and has been used in folk medicine for constipation, inflammation, tumours, and asthma.
S6850 NE 52-QQ57 NE 52-QQ57 is a selective, and orally available antagonist of G-protein coupled receptor 4 (GPR4) with IC50 of 0.07 μM. This compound effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with this chemical significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signalling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2).
Exp Hematol Oncol, 2024, 13(1):13