COMT

Other Methylation Inhibitors

EZH2 PRMT MAT2A LSD1 JMJD G9a/GLP SETD MLL DOT1 HNMT

Cat.No.	Product Name	Information	Product Use Citations
S4021	Tolcapone	Tolcapone (Ro 40-7592) is a selective, potent and reversible catechol-O-methyl transferase (COMT) inhibitor with K_i of 30 nM.	FASEB J, 2022, 36(7):e22399 Viruses, 2021, 13(8)1533 Viruses, 2021, 1533
S6938	Opicapone	Opicapone (BIA 9-1067) is a potent inhibitor of catechol-O-methyltransferase (COMT) with ED50 values of 1.4 mg·kg^-1 in rat erythrocytes. It has the potential to be used in research of Parkinson's disease and motor fluctuations.
S3147	Entacapone	Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with an IC50 of 151 nM. This compound can be used for the research of Parkinson's disease. It serves as an inhibitor of FTO demethylation with an IC50 of 3.5 5M, and can be used for the research of metabolic disorders.	Biochemical and Biophysical Research Communications, October 23, 2015, 567-571 eLife, January 12, 2022, e72668 Elife, 2022, 11e72668

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S4021

Tolcapone

Tolcapone (Ro 40-7592) is a selective, potent and reversible catechol-O-methyl transferase (COMT) inhibitor with K_i of 30 nM.

FASEB J, 2022, 36(7):e22399

Viruses, 2021, 13(8)1533

Viruses, 2021, 1533

S6938

Opicapone

Opicapone (BIA 9-1067) is a potent inhibitor of catechol-O-methyltransferase (COMT) with ED50 values of 1.4 mg·kg^-1 in rat erythrocytes. It has the potential to be used in research of Parkinson's disease and motor fluctuations.

S3147

Entacapone

Entacapone (OR-611) inhibits catechol-O-methyltransferase(COMT) with an IC50 of 151 nM. This compound can be used for the research of Parkinson's disease. It serves as an inhibitor of FTO demethylation with an IC50 of 3.5 5M, and can be used for the research of metabolic disorders.

Biochemical and Biophysical Research Communications, October 23, 2015, 567-571

eLife, January 12, 2022, e72668

Elife, 2022, 11e72668