Technical Data
| Formula | C19H16ClF3N4O3 |
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| Molecular Weight | 440.80 | CAS No. | 2143542-28-1 | |
| Solubility (25°C)* | In vitro | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | 2BAct is a potent, orally bioavailable eIF2B activator exhibiting high selectivity (EC50 = 33 nM). It mitigates neurological impairments induced by persistent integrated stress response. This compound demonstrates blood-brain barrier penetration with enhanced solubility and pharmacokinetic properties compared to ISRIB trans-isomer. |
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| In Vivo | 2BAct (300 μg 2BAct/g of meal; 21 weeks) normalises body weight gain in VWM mice. This compound prevents the appearance of motor deficits, myelin loss and reactive gliosis in VWM mice. It stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response. |
Protocol (from reference)
References
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RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.