Technical Data
| Formula | C43H58N2O17 |
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| Molecular Weight | 874.92 | CAS No. | 112825-05-5 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (114.29 mM) | |
| Water | 50 mg/mL (57.14 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Methyllycaconitine citrate (MLA), the citrate salt of Methyllycaconitine, is a norditerpenoid alkaloid isolated from Delphinium brownii seeds. It acts as a selective antagonist of the α7 neuronal nicotinic acetylcholine receptor (α7nAChR) and exhibits potential as a drug candidate for Alzheimer’s disease treatment. | |
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| In Vivo | Methyllycaconitine citrate (MLA) (6 mg/kg) given alone intraperitoneally does not cause climbing behavior when compare with the saline group. Pretreatment with this compound significantly inhibits methamphetamine (METH)-induced climbing behavior, by about 50%. It does not modify either basal locomotor activity or METH-induced hyperlocomotion. The METH-induced depletion of dopamine neuron terminals is attenuated in mice pretreated with it (250±43 fmol/mg, n=7). A direct effect on body temperature is ruled out because it does not affect basal body temperature (37.0±0.5°C, n=5) or reduce the METH-induced hyperthermia (38.2±0.4°C, n=6, MLA+METH group, n.s. versus METH group). |
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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