In Vivo (Add solvents to the product individually and in order.)
Homogeneous suspension
CMC-NA
≥5mg/ml
Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
Biological Activity
Description
Nadolol (Corgard, Solgol, Anabet, SQ11725) is a non-selective beta-adrenergic antagonist with antihypertensive and antiarrhythmic activities.
Targets
β-adrenergic receptor
In vitro
Nadolol is a new beta-adrenoceptor blocking agent without intrinsic sympathomimetic action and with an extremely long plasma half life. This compound antagonises isoproterenol-induced tachycardia and ouabain-induced arrhythmias in cats, antagonises coronary artery ligation-induced ventricular fibrillation and suppresses ventricular ectopic activity during vagal stimulation in dogs.
In Vivo
In several experimental models (mongrel cats and mongrel dogs), nadolol is effective against cardiac arrhythmias. This anti-arrhythmic activity appears to be related to β-adrenergic receptor blockade, an action that would antagonise the ability of catecholamines to induce arrhythmias by alteration of cardiac automaticity and conductivity. It is also effective in preventing ventricular fibrillation induced by ligation of the left anterior descending coronary artery. This compound has been demonstrated to have a half-life of 4 to 5 hr in animals. It does not block neuromuscular transmission at the junction of the vagus and heart. Furthermore, this chemical does not depress excitability of the heart, as demonstrated by the lack of effect on diastolic threshold in the intact heart of the dog. It is rapidly absorbed from the gastrointestinal tract and remarkably well-tolerated when given in extremely large doses.
Immobilised artificial membrane liquid chromatography vs liposome electrokinetic capillary chromatography: Suitability in drug/bio membrane partitioning studies and effectiveness in the assessment of the passage of drugs through the respiratory mucosa
[ J Chromatogr A, 2024, 1734:465286]
Evaluation of an Ussing Chamber System Equipped with Rat Intestinal Tissues to Predict Intestinal Absorption and Metabolism in Humans
[ Eur J Drug Metab Pharmacokinet, 2022, 10.1007/s13318-022-00780-x]
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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