Technical Data
| Formula | C6H11FO4 |
||||||||||||||
| Molecular Weight | 166.15 | CAS No. | 2089647-47-0 | ||||||||||||
| Solubility (25°C)* | In vitro | DMSO | 33 mg/mL (198.61 mM) | ||||||||||||
| Water | 33 mg/mL (198.61 mM) | ||||||||||||||
| Ethanol | 17 mg/mL (102.31 mM) | ||||||||||||||
| In Vivo (Add solvents to the product individually and in order.) |
|
||||||||||||||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
|||||||||||||||
Preparing Stock Solutions
Biological Activity
| Description | SGN-2FF (2-fluorofucose) is an orally bioavailable small-molecule inhibitor of fucosyltransferase that demonstrated encouraging preclinical antitumor activity in mouse models. |
||
|---|---|---|---|
| Targets |
|
||
| In vitro | SGN-2FF can fully inhibit the fucosylation of the h1F6 mAb at the lowest screening concentration in CHO cells treated with SGN-2FF. The functional effect of inhibiting fucosylation of LS174T cells with SGN-2FF is apparent from its diminished adherence to E-selectin–coated plates. |
||
| In Vivo | In mice, SGN-2FF inhibits fucosylation of endogenously produced antibodies, tumour xenograft membranes, and neutrophil adhesion glycans. SGN-2FF treatment affords complete protection from tumour engraftment in a syngeneic tumour vaccine model, inhibits neutrophil extravasation, and delays the outgrowth of tumour xenografts in immune-deficient mice. |
Protocol (from reference)
| Cell Assay: |
|
|---|---|
| Animal Study: |
|
References
|
Sellecks SGN-2FF Has Been Cited by 1 Publication
| FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension [ Aging Dis, 2023, 14(5):1927-1944] | PubMed: 37196106 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.