Atezolizumab (anti-PD-L1)

Atezolizumab (anti-PD-L1) is a fully humanised, IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1, but not the interaction of PD-L2 with PD-1. MW: 145 KD.

Atezolizumab (anti-PD-L1) Chemical Structure

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73 Citations

17 Nobel Prize winners
have used Selleck products

Shimon Sakaguchi

Nature Communications 2025;16, Article number:1325

David Baker

Dev Cell 2023;58(20):2163-2180.e9.

Michael Houghton

Cell Chem Biol 2020;27(7):780-792.e5

David Julius

Cell 2017;185-198.e16

Charles M. Rice

Cell 2018;172(3):423-438.e25

Quality Control

Batch: Purity: 99% Protein concentration: 5.663mg/ml Endotoxin Level: ＜1EU/mg

99

Specificity

Name	Citation	PD-1/PD-L1 interaction
PD-1/PD-L1 Inhibitor 3	13	+++
BMS-1	13	++
BMS-202	26	+
AUNP-12	3	✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Atezolizumab (anti-PD-L1) is a fully humanised, IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1, but not the interaction of PD-L2 with PD-1. MW: 145 KD.
Features	Human IgG1
Targets/IC₅₀/Ki	hPD-L1 (Cell-free assay) 0.4 nM(Kd)
In vitro	Treatment with single agent atezolizumab exerted a moderate anti-proliferative effect with ~ 30% cell death across all models.
Cell Research	A MTT cell proliferation assays in human spheroids (A) or EPCAM+/CD45- cells (b), untreated or treated with selumetinib, atezolizumab, avelumab, or their combinations.
In vivo	when dual drug–loaded, core-shell nanoparticles (DLTPT) is used in combination with anti PD-L1, the tumour growth is inhibited, which induced immune response against tumour metastasis.
Animal Research	Animal Models: 4T1 tumour–bearing BALB/c mice Dosages: 2.5 or 5 mg/kg Administration: i.v. Reference:^[2]
References	[1] https://pubmed.ncbi.nlm.nih.gov/31196138/ [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864565/

Product Details

CAS No.	1380723-44-3
Isotype	Human IgG1
Source	CHO cells
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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Handling Instructions

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Frequently Asked Questions

Question 1:
How to store the antibody?

Answer:
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.