IFN Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S6494 | CCCP | CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone), an oxidative phosphorylation inhibitor, is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. This compound, the protonophore, can inhibit STING-mediated IFN-β production via disrupting mitochondrial membrane potential (MMP). |
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| S3544 | VBIT-4 | VBIT-4 is a voltage-dependent anion channel (VDAC) oligomerization inhibitor that decreases mitochondrial DNA (mtDNA) release, type I interferon (IFN) signalling, neutrophil extracellular traps, and disease severity in a mouse model of systemic lupus erythematosus. |
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| S7259 | FLLL32 | FLLL32 is a potent JAK2/STAT3 inhibitor with an IC50 of <5 μM. This compound inhibits the induction of STAT3 phosphorylation by IFNα and IL-6 in breast cancer cells. |
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| S3023 | Bufexamac | Bufexamac (Bufexamic acid) is a COX inhibitor for IFN-α release with EC50 of 8.9 μM. |
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| S7904 | 2',3'-cGAMP Sodium Salt | 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ). 2',3'-cGAMP binds to STING with Kd of 3.79 nM. |
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| S3924 | Ginsenoside Rb1 | Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. This compound, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. It also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. This chemical reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS. |
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| S5588 | Creatine | Creatine (Methylguanidoacetic acid) is a nitrogenous organic acid that occurs naturally in vertebrates. It facilitates the recycling of adenosine triphosphate (ATP) primarily in muscle and brain tissue. This compound can inhibit the JAK-STAT1 signal transmission by inhibiting the interaction of IFN-γ receptors with JAK2 in an ATP-independent manner, thereby inhibiting downstream pro-inflammatory gene expression. |
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| S8954 | G10 (STING agonist-1) | G10 (STING agonist-1) is a novel human-specific STING agonist that triggers IFN regulatory factor 3 (IRF3)/ type I interferon (IFN)-associated transcription in human fibroblasts. This compound potently reduces growth of Chikungunya virus (CHIKV) with IC90 of 8.01 μM and blocks replication of Alphavirus species Venezuelan Equine Encephalitis Virus (VEEV) with IC90 of 24.57 μM. |
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| S0437 | SAR-20347 | SAR-20347 is a potent inhibitor of TYK2, JAK1, JAK2 and JAK3 with IC50 of 0.6 nM, 23 nM, 26 nM and 41 nM, respectively. This compound inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signalling. |
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| S6727 | AX-024 HCl | AX-024 HCl blocks the interaction of the CD35 PRS with SH3.1(Nck). This compound also inhibits IL-6, TNF-α, IFN-γ, IL-10 and IL-17A. |
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| S1833 | Butoconazole nitrate | Butoconazole nitrate (RS-35887) is an anti-Fungal agent that inhibits PHA-stimulated release of cytokines—IL-2, TNFα, IFN and GM-CSF from human peripheral blood lymphocytes (IC50 of 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively). | ||
| S7905 | 3',3'-cGAMP | 3',3'-cGAMP (3',3'-cyclic GMP-AMP, Cyclic GMP-AMP, cGAMP) activates the endoplasmic reticulum (ER)-resident receptor stimulator of interferon genes (STING), thereby inducing an antiviral state and the secretion of type I IFNs. |
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