MDM2/MDMX Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S8065 | Nutlin-3b | Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor with an IC50 value of 13.6 μM, a 150-fold less potent (+)-enantiomer of this compound compared to the opposite (-)-enantiomer Nutlin-3a. |
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| S8403 | MX69 | MX69 is a MDM2/XIAP inhibitor that binds to MDM2 RING protein with binding Kd values of 2.34 μM. It is used for cancer treatment. |
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| S7489 | YH239-EE | YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer. |
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| S8546 | Alrizomadlin | Alrizomadlin (APG-115, AA-115) is a highly potent and efficacious inhibitor of MDM2 and binds to MDM2 with an IC50 of 3.8 nM. It exhibits potent antiproliferative and apoptogenic activities and also significantly reduces tumour burden and prolonged survival in AML xenograft models. | ||
| E0051 | SJ-172550 | SJ 172550 is the first MDMX inhibitor that binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. | ||
| S0167 | RO8994 | RO8994 is a potent and selective small-molecule MDM2 inhibitor with IC50 values of 5 nM in HTRF binding assays and 20 nM in MTT proliferation assays, respectively. | ||
| E1537 | MMRi62 | MMRi62 is a ferroptosis inducer, targeting MDM2-MDM4 with a Kd value of 1.39 μM. It exhibits P53-independent pro-Apoptosis activity against pancreatic ductal adenocarcinoma (PDAC) cells and induces autophagy. | ||
| S8703 | Milademetan (DS-3032) | Milademetan (RAIN-32, DS-3032) is an oral, selective inhibitor of the MDM2-p53 complex that reactivates p53 to induce cancer cell apoptosis and exhibits an anti-tumour effect. | ||
| S7426 | AMG 232 ( KRT-232 ) | AMG 232 (Navtemadlin) is a potential, selective inhibitor of the MDM2–p53 interaction, with an IC50 of 0.6 nM and binds to MDM2 with a Kd of 0.045 nM. It also demonstrated antitumour activity in vivo in a variety of tumour types with different genetic backgrounds. | ||
| S6900 | MD-224 | MD-224 is a highly potent and effective degrader of the Human murine double minute 2 (MDM2) protein, the main cellular inhibitor of the tumour suppressor p53. It strongly inhibits cell growth in leukaemia cell lines with wild-type p53 and induces complete and lasting tumour regression in the RS4;11 xenograft tumour model. | ||
| S0901 | SP141 | SP141 is a new class of MDM2 inhibitor that promotes MDM2 auto-ubiquitination and degradation, and reduces levels of MDM2 in pancreatic cancer cell lines, as well as their proliferation and ability to form tumours in nude mice. This compound inhibits human pancreatic cancer cell growth with IC50 values of less than 0.5 μM (0.38–0.50 μM) in a p53-independent manner. | ||
| S2341 | (-)-Parthenolide | (-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions. |
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