Mechanosensitive Channel antagonists

Cat.No. Product Name Information Product Use Citations Product Validations
S2953 Dooku1 Dooku1 is an analog of Yoda1 with antagonist activity against the mechanosensitive Piezo1 channel. This compound inhibits 2 μM Yoda1-induced Ca2+-entry with IC50 of 1.3 μM in HEK 293 cells and 1.5 μM in HUVECs, respectively.
Sci Adv, 2023, 9(22):eadg0478