Home Epigenetics MicroRNA

MicroRNA

Other Epigenetics Inhibitors

Histone Methyltransferase BET DNA Methyltransferase p300/CBP Histone Demethylase Histone Acetyltransferase NSD EZH1 RNA Methyltransferase SF3B
Cat.No. Product Name Information Product Use Citations Product Validations
S1288 Camptothecin (CPT) Camptothecin (CPT) is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM in a cell-free assay. Camptothecin induces apoptosis in cancer cells via microRNA-125b-mediated mitochondrial pathways. Phase 2.
Cell Stem Cell, 2025, S1934-5909(25)00256-5
Nat Commun, 2025, 16(1):4491
EMBO J, 2025, 10.1038/s44318-025-00370-y
Verified customer review of Camptothecin (CPT)
S3084 Guanosine 5'-triphosphate trisodium salt

Guanosine 5'-triphosphate (5'-GTP, Guanosine triphosphate, H4GTP) trisodium salt is an enhancer of myogenic cell differentiation in murine cells. Guanosine 5'-triphosphate trisodium salt up-regulates MicroRNA (specifically miR133a and miR133b) and myogenic regulator factor and induces human myogenic precursor cells to release exosomes stuffed with guanosine based molecules (mainly guanosine) in the extracellular milieu.
E3687 Radix Actinidiae Extract Radix Actinidiae Extract is derived from Radix Actinidiae, also known as the root of Actinidia chinensis Planch., which can play an anticancer role by regulating microRNA (miRNA) expression.
S9665 Motixafortide (BL-8040, BKT140) Motixafortide (BL-8040, BKT140, TF 14016, 4-fluorobenzoyl, 4F-benzoyl-TN14003, T140) is an antagonist of CXCR4 with IC50 of ~1 nM. BL-8040 induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
King's College London, 2023,
S3309 Solasodine Solasodine (Purapuridine, Solancarpidine, Solasodin, Salasodine, Salasdine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. This compound reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase (EMMPRIN), but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK). It downregulates oncogenic microRNA-21 (miR-21), which has been known to target RECK. This chemical also reduces PI3K/Akt signalling pathways and downregulates expression of miR-21.
S9067 Pseudoprotodioscin Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. This compound inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.