NLRP3 Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S9899	BMS-986299	BMS-986299 is a novel NLRP3 agonist that induces IL8 release to activate natural killer (NK) cells.
E4741^New	AZD4144	AZD4144 (Compound 25) is a potent and selective inhibitor of the NLRP3 inflammasome with an IC50 of 76 nM in the nigericin-triggered speck formation assay. It binds directly to the NACHT domain of NLRP3, stabilising its inactive conformation to prevent inflammasome activation. AZD4144 also inhibits LPS/ATP-induced release of pro-inflammatory cytokines IL-1β and IL-18 in mice with an IC50 of 54 nM and exhibits potential for treating inflammatory diseases.
E4663	INF195	INF195 is an NLRP3 inhibitor which inhibits NLRP3-driven macrophage pyrodeath and IL-1β release. At low dose, INF195 can reduce the infarct size of isolated mouse hearts and effectively prevent myocardial ischemia/reperfusion injury.
E3367	Garlic chives Extract	Garlic chives Extract is extracted from Allium tuberosum, which provides a new therapeutic in the treatment of NLRP3 inflammasome-driven diseases.
E6072^New	ATP dimagnesium	ATP dimagnesium (Adenosine 5'-triphosphate dimagnesium) is a central molecule in energy metabolism, driving cellular pumps and acting as a coenzyme. It also functions as an endogenous signalling molecule that modulates immune responses and activates the NLRP3 inflammasome, contributing to host defence during bacterial infections.
E1281	Dimethyl itaconate	Dimethyl itaconate can reprogram neurotoxic to neuroprotective primary astrocytes through the regulation of LPS-induced Nod-like receptor protein 3 (NLRP3) inflammasome and nuclear factor 2/heme oxygenase-1 (NRF2/HO-1) pathways.
E1872	Selnoflast	Selnoflast(RO-7486967) is a selective and reversible small molecule inhibitor of NLRP3 inflammasome, with the potential to treat moderate to severe active ulcerative colitis.
S6653	Nigericin sodium salt	Nigericin sodium salt is an antibiotic derived from Streptomyces hygroscopicus that works by acting as an H⁺, K⁺, and Pb²⁺ ionophore. Nigericin can activate NLRP3 inflammasome to induce pro-inflammatory and immunostimulatory processes.	Nature, 2025, 10.1038/s41586-025-09222-5 Adv Sci (Weinh), 2025, 12(43):e10412 J Hazard Mater, 2025, 492:138145
S3871	Muscone	Muscone (3-Methylcyclopentadecanone, Methylexaltone), a flavouring ingredient, is an organic compound that is the primary contributor to the odour of musk and also a potent anti-inflammatory agent. This compound significantly downregulates the levels of LPS-induced inflammatory cytokines and inhibits NF-κB and NLRP3 inflammasome activation in BMDMs. It remarkably decreases the levels of inflammatory cytokines (IL-1β, TNF-α and IL-6).	Ecotoxicol Environ Saf, 2025, 292:117961 Invest Ophthalmol Vis Sci, 2025, 66(5):21 Toxicol Appl Pharmacol, 2025, 503:117494
S3290	Procyanidin B2 (PCB2)	Procyanidin B2 (PCB2), a natural flavonoid found in commonly consumed foods, possesses anti-inflammatory, anti-oxidant and anti-cancer activities. It activates PPARγ to induce M2 polarization in mouse macrophages and significantly suppresses the activation of NLRP3 inflammasome in the lung tissue induced by paraquat in the rat model.	BMC Cardiovasc Disord, 2024, 24(1):231 Front Pharmacol, 2021, 12:639651
S3939	4'-Methoxyresveratrol	4'-Methoxyresveratrol is a stilbenoid found in the Chinese herb Gnetum cleistostachyum. 4'-Methoxyresveratrol alleviates AGE-induced inflammation through suppressing RAGE-mediated MAPK/NF-κB signaling pathway and NLRP3 inflammasome activation.
E7041	Desmosterol	Desmosterol is the immediate unsaturated precursor of cholesterol and the final biosynthetic intermediate in the Bloch pathway and a key activator of Liver X Receptors (LXR) while inhibiting SREBP to regulate lipid homeostasis. Its reduction promotes mitochondrial ROS production in macrophages and activates the NLRP3 inflammasome exhibiting potential for research in inflammation, Metabolism, and cardiovascular diseases.
E3652	Rehmanniae radix praeparata Extract	Rehmanniae radix praeparata Extract is extracted from Rehmanniae radix praeparata, which can improve diabetes through AMPK-mediated NF-κB/NLRP3 signaling pathway.
E5801^New	NLRP3/AIM2-IN-3	NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with species-specific effects on NLRP3 and AIM2 inflammasome-mediated pyroptosis. It demonstrates potent inhibition of pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 μM. It also disrupts the interaction between NLRP3 or AIM2 and the adaptor protein ASC, effectively preventing ASC oligomerisation and blocking inflammasome assembly.
E4642^New	CVN293	CVN293 is a potent, selective, and brain permeable small-molecule inhibitor of potassium (K+) ion channel KCNK13 with IC50s of 49 nM and 28 nM for hKCNK13 and mKCNK13, respectively. It also inhibits NOD-like receptor protein 3 (NLRP3) inflammasome-mediated IL-1ß production in LPS-stimulated primary neonatal murine microglia with an IC50 of 24 nM and has potential applications in Alzheimer’s disease research.
E0225	Licochalcone B	Licochalcone B (Lico B), extracted from Glycyrrhiza uralensis Fisch, induces cell cycle arrest and Apoptosis in human hepatoma cell HepG2. This compound specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction.