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Levetiracetam (UCB-L059) Calcium Channel Inhibitor

Name: Levetiracetam (UCB-L059)
Brand: Selleck Chemicals
SKU: S1356
Rating: 5 (10 reviews)

Cat.No.: S1356

Levetiracetam (UCB-L059, SIB-S1) is an anticonvulsant medication used to treat epilepsy and an agonist of muscarinic acetylcholine receptors (mAChR). This compound also modulates the presynaptic P/Q-type voltage-dependent calcium (Ca2+) channel.

Chemical Structure

Molecular Weight: 170.21

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Quality Control

Batch: Purity: 99.98%

99.98

Related Targets	CFTR CRM1 CD markers AChR Sodium Channel Potassium Channel GABA Receptor TRP Channel ATPase GluR
Other Calcium Channel Inhibitors	Bay K 8644 BAPTA-AM Tetrandrine Flunarizine 2HCl Nilvadipine Cilnidipine YM-58483 (BTP2) Ionomycin Imperatorin Manidipine 2HCl

Chemical Information, Storage & Stability

Molecular Weight	170.21	Formula	C₈H₁₄N₂O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	102767-28-2	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	UCB-L059, SIB-S1			Smiles	CCC(C(=O)N)N1CCCC1=O

Solubility

In vitro
Batch:

DMSO : 34 mg/mL (199.75 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 34 mg/mL

Ethanol : 34 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	Saline Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	30.000mg/ml (176.25mM)	Taking the 1 mL working solution as an example, add 30 mg of this product to 1 ml of physiological saline (0.9% NaCL solution), mix evenly to make it clear, The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	Calcium channel
In vitro	Levetiracetam (UCB-L059) and related compounds bind to SV2A expressed in fibroblasts, indicating that SV2A is sufficient for its binding. This compound irreversibly inhibits the high-voltage-activated (HVA) calcium current by approximately 18% on the average in freshly isolated CA1 hippocampal neurons of rats. It selectively inhibits N-type Ca2+ channels of CA1 pyramidal hippocampal neurons. Levetiracetam also reverses the inhibitory effect of DMCM on GABA-elicited currents in hippocampal neurons.
In vivo	Levetiracetam (UCB-L059) (17 mg/kg) produces a potent suppression of sound-induced clonic convulsions in mice, and this protective effect is significantly abolished by co-administration of the beta-carboline FG 7142. It exerts potent anticonvulsant activity against both focal and secondarily generalized seizures in fully amygdala-kindled rats, i.e. , a model of temporal lobe epilepsy. This compound (13 mg/kg, 27 mg/kg or 54 mg/kg, i.p.) dose-dependently suppresses the increase in seizure severity and duration induced by repeated amygdala stimulation. It has a relatively short half-life (about 2-3 hours) in rats. Levetiracetam (5.4 mg/kg to 96 mg/kg i.p.) dose-dependently inhibits both wild running and tonic-clonic convulsions in the audiogenic-seizure prone rat. It markedly suppresses spontaneous spike-and-wave discharge (SWD) but leaves the underlying EEG trace normal in the GAERS model of petit mal epilepsy.
References	[1] https://pubmed.ncbi.nlm.nih.gov/15917812/ [2] https://pubmed.ncbi.nlm.nih.gov/11879381/ [3] https://pubmed.ncbi.nlm.nih.gov/12086975/ [4] https://pubmed.ncbi.nlm.nih.gov/9454787/ [5] https://pubmed.ncbi.nlm.nih.gov/8991787/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-10-24)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07220902	NOT_YET_RECRUITING	Severe Preeclampsia; Eclampsia Preeclampsia	Nebraska Methodist Health System	2026-01-01	PHASE3
NCT06442748	RECRUITING	Seizures; Brain Tumors; Antiepileptics; Levetiracetam	Tata Memorial Centre	2024-07-04	PHASE3
NCT07336992	NOT_YET_RECRUITING	Spontaneous Intracerebral Hemorrhage	Hospices Civils de Lyon	2026-10-02	PHASE3
NCT07758062	NOT_YET_RECRUITING	Glioblastoma	Tianjin Medical University General Hospital	2026-09-01	PHASE2
NCT06907173	RECRUITING	Status Epilepticus	University of Virginia	2026-03-06	PHASE3
NCT07130786	RECRUITING	Seizures; Primary Motor Cortex; Brain Metastases From Non-small Cell Lung Cancer (NSCLC); Brain Metastases, Adult; Brain Metastases From Extra-cranial Solid Tumors	Ayal A. Aizer, MD	2025-12-23	PHASE2

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