For research use only. Not for use in humans.

Abrilumab (Anti-Integrin a4b7 ITGA4 & ITGB7)

Cat.No.A2761 Purity:99%

Abrilumab (Anti-Integrin a4b7 ITGA4 & ITGB7) is a fully human monoclonal immunoglobulin G2 antibody that targets the alpha4beta7 Integrin and prevents interaction with MADCAM-1. It has the potential to be used in research on inflammatory bowel disease (IBD). MW: 143.8 kD.

Quality Control

Batch: A276101 Purity: 99% Protein concentration: 6.64mg/ml Endotoxin Level: ＜1EU/mg

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COA
SDS
Datasheet

Specificity

Name	Citation	Integrin
Cilengitide trifluoroacetate	70	+++
A-205804	6	++
Cyclo(RGDyK) TFA	14	++
SB273005	27	++++
RGD peptide (Arg-Gly-Asp)	26	✔
ATN-161	22	✔
Cyclo(-RGDfK) TFA	13	✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Abrilumab (Anti-Integrin a4b7 ITGA4 & ITGB7) is a fully human monoclonal immunoglobulin G2 antibody that targets the alpha4beta7 Integrin and prevents interaction with MADCAM-1. It has the potential to be used in research on inflammatory bowel disease (IBD). MW: 143.8 kD.
References	[1] https://pubmed.ncbi.nlm.nih.gov/33935763/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1342290-43-0
Molecular Weight	143.8
Isotype	Human IgG2
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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