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Ambroxol Sodium Channel inhibitor

Name: Ambroxol
Brand: Selleck Chemicals
SKU: S5710
Rating: 5 (1 reviews)

Cat.No.S5710

Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels.

Chemical Structure

Molecular Weight: 378.10

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Quality Control

Batch: S571001 DMSO]76 mg/mL]false]]]false]]]false Purity: 99.9%

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.9

Related Targets	CFTR CRM1 CD markers AChR Calcium Channel Potassium Channel GABA Receptor TRP Channel ATPase GluR
Other Sodium Channel Inhibitors	Camostat Mesilate A-803467 cariporide Tolperisone HCl Vinpocetine Veratramine Bulleyaconi cine A Ambroxol HCl Benzocaine Nefopam HCl

Chemical Information, Storage & Stability

Molecular Weight	378.10	Formula	C₁₃H₁₈Br₂N₂O	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	18683-91-5	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O

Solubility

In vitro
Batch:

DMSO : 76 mg/mL (201.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	6.000mg/ml (15.87mM)	Taking the 1 mL working solution as an example, add 50 μL of 120 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04405596	Not yet recruiting	Lewy Body Disease	Lawson Health Research Institute	January 2025	Phase 1\|Phase 2
NCT05778617	Not yet recruiting	Parkinson Disease	University College London	September 2023	Phase 3
NCT05558878	Not yet recruiting	Diabetic Neuropathy Peripheral	Ain Shams University	October 1 2022	Not Applicable
NCT05287503	Active not recruiting	Parkinson Disease\|GBA Gene Mutation	Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta\|IRCCS National Neurological Institute C. Mondino Foundation\|University of Campania Luigi Vanvitelli	February 15 2022	Phase 2
NCT04388969	Recruiting	Gaucher Disease\|Parkinson Disease\|GBA Gene Mutation	Shaare Zedek Medical Center	May 6 2020	--

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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