For research use only. Not for use in humans.

Anti-ACVR1 / ALK-2 (DS-6016a)

Synonyms: Prafnosbart Cat.No.A2621

Anti-ACVR1 / ALK-2 (DS-6016a) monoclonal antibody targeting ALK-2. It can be used in the treatment of fibrodysplasia ossificans progressiva (FOP). MW :145.56.

Quality Control

Cited in Nature Medicine for its top-tier quality
SDS
Datasheet

Specificity

Name	Citation	ALK	Others
TAE684 (NVP-TAE684)	83	+
AP26113-analog (ALK-IN-1)	4	++++	EGFR(C797S/del19),IGF1R,EGFR(del19)
GSK1838705A	18	+++	Insulin Receptor,IGF-1R
AZD3463	7	++	IGF-1R
ASP3026	4	+
Belizatinib (TSR-011)	0	++	TrkC,TrkB,TrkA
Repotrectinib (TPX-0005)	12	+	Src

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Anti-ACVR1 / ALK-2 (DS-6016a) monoclonal antibody targeting ALK-2. It can be used in the treatment of fibrodysplasia ossificans progressiva (FOP). MW :145.56.
References	[1] https://pubmed.ncbi.nlm.nih.gov/35536530/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	2566473-71-8
Molecular Weight	145.56
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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