For research use only. Not for use in humans.

Anti-IL-4Ra / CD124 (MEDI2045)

Synonyms: null Cat.No.A2972 Purity:99%

Anti-IL-4Ra / CD124 (MEDI2045) is a high-affinity human and Cynomolgus cross-reactive antibody that blocks the functional interaction of IL-4 and IL-13 with their obligate receptor, IL-4Ra. MEDI 2045 has the potential to treat severe, uncontrolled asthma. MW: 143.76 KD.

Quality Control

Batch: A297201 Purity: 99% Protein concentration: 7.14mg/ml Endotoxin Level: ＜1EU/mg

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COA
SDS
Datasheet

Specificity

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Anti-IL-4Ra / CD124 (MEDI2045) is a high-affinity human and Cynomolgus cross-reactive antibody that blocks the functional interaction of IL-4 and IL-13 with their obligate receptor, IL-4Ra. MEDI 2045 has the potential to treat severe, uncontrolled asthma. MW: 143.76 KD.
References	[1] https://sci-hub.hkvisa.net/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a5668

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

Molecular Weight	143.76
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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