Clone No.:MR-1
The MR-1 monoclonal antibody reacts with mouse CD154 also known as CD40 ligand. The MR-1 monoclonal antibody has been reported to inhibit in vitro activation of B lymphocytes by blocking the binding of CD154 with CD40 on T helper cells as well as inhibit the formation of germinal centers and disrupt antigen-specific T cell responses. Additionally, the MR-1 antibody blocks interactions of T cells and antigen-presenting cells in vitro and blocks the development of experimental autoimmune disease in vivo.
| Molecular Weight | 150 kDa |
|---|---|
| Clone | MR-1 |
| Immunogen | Activated mouse Th1 clone D1.6 |
| Isotype | Armenian Hamster IgG |
| Application | in vivo/vitro blocking of CD40/CD40L,WB |
| Purification | protein A |
| Sterility | 0.2 μM filtered |
| Formulation | PBS buffer, pH 7.0 |
| Storage | Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles |
*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)
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