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BAY-8002 MCT inhibitor

Name: BAY-8002
Brand: Selleck Chemicals
SKU: S8747
Rating: 5 (6 reviews)

Cat.No.S8747

BAY-8002 is a novel MCT1 inhibitor and potently suppresses bidirectional lactate transport. This compound significantly increases intratumour lactate levels and transiently modulates pyruvate levels.

Chemical Structure

Molecular Weight: 415.85

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Quality Control

Batch: Purity: 99.19%

99.19

Related Targets	CFTR CRM1 CD markers AChR Calcium Channel Sodium Channel Potassium Channel GABA Receptor TRP Channel ATPase
Other MCT Inhibitors	AZD3965 α-cyano-4-hydroxycinnamic acid(α-CHCA) VB124 AR-C155858 Syrosingopine 7ACC2 AZD0095 MSC-4381 MCT-IN-1

Chemical Information, Storage & Stability

Molecular Weight	415.85	Formula	C₂₀H₁₄ClNO₅S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	724440-27-1	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	C1=CC=C(C=C1)S(=O)(=O)C2=CC(=C(C=C2)Cl)C(=O)NC3=CC=CC=C3C(=O)O

Solubility

In vitro
Batch:

DMSO : 83 mg/mL (199.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 28 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3mg/ml (7.21mM)	Taking the 1 mL working solution as an example, add 50 μL of 60 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	6mg/ml (14.43mM)	Taking the 1 mL working solution as an example, add 50 μL of 120 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	MCT
In vitro	BAY-8002 inhibits cellular SNARF-5 fluorescence change with an IC50 of 85 (±6) nmol/L in MCT1-expressing DLD-1 cells and displays excellent selectivity against MCT4 (IC50 > 50 μmol/L in EVSA-T cells). This compound is a dual inhibitor of MCT1 and MCT2.
References	[1] https://pubmed.ncbi.nlm.nih.gov/30115664/

Applications

Methods	Biomarkers	Images	PMID
Growth inhibition assay	Cell viability		30115664

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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