For research use only. Not for use in humans.

Burosumab (Anti-FGF23)

Synonyms: KRN23 Cat.No.A2499 Purity:99%

Burosumab (Anti-FGF23) is a neutralising antibody, targeting human fibroblast growth factor 23 (FGF23). It can be used for the research of X-linked hypophosphatemia (XLH) and tumour-induced osteomalacia. MW: 145.5 KD.

Quality Control

Batch: A249901 Purity: 99% Protein concentration: 5.19mg/ml Endotoxin Level: ＜1EU/mg

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COA
SDS
Datasheet

Specificity

Name	Citation	FGFR1	FGFR2	FGFR3	FGFR4	Others
PD173074	124	++				VEGFR2
Dovitinib (TKI-258)	52	+++		+++		FLT3,c-Kit,VEGFR3/FLT4
AZD4547 (Fexagratinib)	145	++++	++++	++++		KDR
Danusertib (PHA-739358)	46	++				Aurora A,Abl,TrkA
Brivanib (BMS-540215)	10	+				VEGFR2,Flk1,VEGFR1
MK-2461	4	+	++	+		c-Met (M1250T),c-Met (Y1235D),c-Met (Y1230H)
Brivanib Alaninate (BMS-582664)	2	+				VEGFR2,Flk1,VEGFR1
SSR128129E	9	+
H3B-6527	12				++++
PRN1371	2	++++	++++	+++	++	CSF1R
PD-166866	15	+
Fisogatinib (BLU-554)	10				+++
S49076	1	++	++	++		Met,Mer,Axl
SU 5402	24	++				VEGFR2,PDGFRβ
BLU9931	21			+	++++
FIIN-2	5	+++	+++	++	++
Dovitinib (TKI258) Lactate monohydrate	31	+++		+++		FLT3,c-Kit,VEGFR3/FLT4
Zoligratinib (Debio-1347)	12	++	+++	++	+
LY2874455	15	++++	++++	+++	+++	VEGFR2

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Burosumab (Anti-FGF23) is a neutralising antibody, targeting human fibroblast growth factor 23 (FGF23). It can be used for the research of X-linked hypophosphatemia (XLH) and tumour-induced osteomalacia. MW: 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1610833-03-8
Molecular Weight	144 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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