For research use only. Not for use in humans.

Cetuximab-MMAE

Cat.No.D4022 Purity:99%

Cetuximab-MMAE is an antibody-drug conjugate composed of an anti-EGFR monoclonal antibody and a cytotoxic tubulin polymerase inhibitor conjugated through an MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) type linker.

CAS No.

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Quality Control

Batch: D402201 Purity: 99% Protein concentration: 6.98mg/ml Endotoxin Level: ＜1EU/mg

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COA
SDS
Datasheet

Specificity

Name	Citation	EGFR/ErbB1	HER2/ErbB2	ErbB3	ErbB4	mutant EGFR	Others
Canertinib (CI-1033)	48	++++	+++
AG-490	132	+
CP-724714	109		++
WZ4002	34	++++
Sapitinib (AZD8931)	50	+++	+++	+++
CUDC-101	23	+++	++				HDAC,HDAC1,HDAC6
AG-1478	99	+++
PD153035 HCl	17	++++
Pelitinib (EKB-569)	11	+	+				Src,MEK/ERK,Raf
AEE788 (NVP-AEE788)	13	++++	+++		+		c-Abl,FLT1,c-Fms
AC480 (BMS-599626)	10	++	++		+
AP26113-analog (ALK-IN-1)	4					++	ALK,IGF1R,INSR
WZ3146	2	++++
Allitinib tosylate	18	++++	+++		++++
Rociletinib (CO-1686)	37	++
Varlitinib	8	+++	++++
Icotinib (BPI-2009H)	10	+++
TAK-285	4	++	++		+		MEK1,Aurora B,LCK
WHI-P154	11	+++					Src,VEGFR,JAK3
Daphnetin	4	+					PKA,PKC
PD168393	6	++++
CNX-2006	2	++				++
Tyrphostin 9	1	+					PDGFR
AG-18	1	+
Lifirafenib (BGB-283)	6	++				+	WT A-RAF,C-RAF (Y340/341D),BRAF(V600E)
Nazartinib (EGF816)	6	+				+
Zorifertinib (AZD3759)	6	++++
CL-387785 (EKI-785)	5	++++
Poziotinib (NOV120101, HM781-36B)	35	+++	+++		++
AZ5104	4	++++			+++		ACK1,BLK,BRK
HER2-Inhibitor-1	1		✔
WZ8040	3	✔
Genistein	35	✔					topo II
Naquotinib(ASP8273)	1	✔
Olmutinib (BI 1482694)	6	✔					BTK
Butein	2	✔
Chrysophanic Acid	3	✔					mTOR

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Cetuximab-MMAE is an antibody-drug conjugate composed of an anti-EGFR monoclonal antibody and a cytotoxic tubulin polymerase inhibitor conjugated through an MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) type linker.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

ADC antibody	Cetuximab
ADC cytotoxin	MMAE
Formulation	1xPBS
Storage	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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