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CH7233163 EGFR inhibitor

Name: CH7233163
Brand: Selleck Chemicals
SKU: S9711
Rating: 5 (1 reviews)

Cat.No.S9711

CH7233163 is a non-covalent ATP competitive inhibitor of EGFR-tyrosine kinase with antitumor activities against tumour with EGFR-Del19/T790M/C797S.

Chemical Structure

Molecular Weight: 669.72

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Quality Control

Batch: S971101 DMSO]100 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 98.91%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

98.91

Related Targets	VEGFR PDGFR FGFR c-Met Src MEK CSF-1R FLT3 HER2 c-Kit
Other EGFR Inhibitors	Lazertinib (YH25448) Icotinib Hydrochloride Sunvozertinib AG-490 AG-1478 Canertinib (CI-1033) WZ4002 Rociletinib (CO-1686) Poziotinib (NOV120101, HM781-36B) Genistein

Chemical Information, Storage & Stability

Molecular Weight	669.72	Formula	C₃₁H₃₄F₃N₉O₃S	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	unknown	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (149.31 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Mechanism of Action

Targets/IC₅₀/Ki	EGFR
In vitro	CH7233163 shows potent antitumor activities against tumour with EGFR-Del19/T790M/C797S in vitro. This compound potently inhibits the proliferation of Del19/T790M/C797S_NIH3T3 cells with IC50 of 20 nmol/L. It potently and dose-dependently blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. This chemical can inhibit Del19/T790M/C797S signalling.
In vivo	Pharmacodynamic study is performed using Del19/T790M/C797S_NIH3T3 xenografted tumours in mice. CH7233163 clearly inhibits EGFR phosphorylation after oral administration and potent tumour regression is observed. This compound has potent therapeutic efficacy against tumours with EGFR-Del19/T790M/C797S in vivo.
References	[1] https://pubmed.ncbi.nlm.nih.gov/32943545/

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