research use only
Citral Immunology & Inflammation related chemical
Cat.No.S5138
Chemical Structure
Molecular Weight: 152.23
Quality Control
| Related Targets | PD-1/PD-L1 CXCR STING AhR CD markers Interleukins Anti-infection Antioxidant COX Histamine Receptor |
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| Other Immunology & Inflammation related Inhibitors | Cl-amidine Bestatin (Ubenimex) Bindarit (AF 2838) Tranilast Tempol Sinomenine GI254023X (GI4023) ATP Geniposidic acid CORM-3 |
Chemical Information, Storage & Stability
| Molecular Weight | 152.23 | Formula | C10H16O |
Storage (From the date of receipt) | 2 years -20°C liquid |
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| CAS No. | 5392-40-5 | -- | Storage of Stock Solutions |
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Solubility
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In vitro |
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Mechanism of Action
| In vitro |
Citral is the mixture of two isomeric acyclic monoterpene aldehydes, the trans-isomer geranial or Citral A and the cis-isomer neral or Citral B. Several pharmacological activities of this compound have been documented such as anti-inflammatory effects, antimicrobial activities against Gram-positive and Gram-negative bacteria, fungi, and some protozoa, and anticancer activities against some cancer cell lines including leukemic, breast, and lymphoma cells. Treatment with this chemical results in an activation of caspase-3, leading to apoptosis in human U937, HL60, and NB4 and mouse RL12 and BS-24-1 leukemic cell lines. Moreover, it inhibits human breast cancer cell MCF-7 growth and induces cycle arrest in G2/M phase. This compound induces human lymphoma Ramos cell apoptosis by activating caspase activity in a concentration and time-dependent manner but has no effect on cell distribution in the cell cycle.
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| In vivo |
Citral can block the L-type calcium channels and shows a significant anti-inflammatory effect in the carrageenan model. It has a very important anti-inflammatory activity in the test of croton oil-induced ear oedema in mice. Treatment with this compound in mice with lung injury induced by LPS inhibits TNF-α, IL-1β, and IL-6 levels both in vivo and in vitro.
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