research use only
Cat.No.S3300
| Related Targets | Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism |
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| Other Fatty Acid Synthase Inhibitors | Denifanstat (TVB-2640) Fatostatin TVB-3664 C75 Betulin FT113 C75 trans Praeruptorin B Sodium palmitate TVB-3166 |
| Molecular Weight | 404.41 | Formula | C21H24O8 |
Storage (From the date of receipt) | 3 years -20°C powder |
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| CAS No. | 30197-14-9 | -- | Storage of Stock Solutions |
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| Synonyms | DC, DES | Smiles | COC1=CC=C(C=C1)/C=C/C2=CC(=CC(=C2)O)OC3OC(CO)C(O)C(O)C3O | ||
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In vitro |
DMSO
: 100 mg/mL
(247.27 mM)
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In vivo |
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Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
| Targets/IC50/Ki |
FAS/FASN
glucose
(in rat everted gut sleeves) 30.9 μM
glucose
(in rabbit intestinal membrane vesicles) 148.3 μM
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References |
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(data from https://clinicaltrials.gov, updated on 2024-05-22)
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT06386003 | Not yet recruiting | Post Traumatic Stress Disorder|PTSD|Chronic PTSD |
Unity Health Toronto|Toronto Metropolitan University|University of Ottawa |
August 2024 | Phase 2 |
| NCT06319430 | Not yet recruiting | Physical Disability |
University of Manitoba|Rehabilitation Centre for Children Canada |
June 1 2024 | Not Applicable |
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