For research use only. Not for use in humans.

Dostarlimab (Anti-PDCD1 / PD-1 / CD279)

Synonyms: null Cat.No.A2835 Purity:99%

Dostarlimab (Anti-PDCD1 / PD-1 / CD279) is a humanised monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 ((PD-1 programmed death-1), with potential immune checkpoint inhibitory and antineoplastic activities. MW: 144.18 KD.

Quality Control

Batch: A283501 Purity: 99% Protein concentration: 4.22mg/ml Endotoxin Level: ＜1EU/mg

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

Specificity

Name	Citation	PD-1/PD-L1 interaction
PD-1/PD-L1 Inhibitor 3	13	+++
BMS-1	13	++
BMS-202	26	+
AUNP-12	3	✔

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Dostarlimab (Anti-PDCD1 / PD-1 / CD279) is a humanised monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 ((PD-1 programmed death-1), with potential immune checkpoint inhibitory and antineoplastic activities. MW: 144.18 KD.
References	[1] https://pubmed.ncbi.nlm.nih.gov/34313545/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	2022215-59-2
Molecular Weight	144.18
Isotype	Human IgG4SP
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.