For research use only. Not for use in humans.

Dupilumab (anti-IL-4Rα)

Synonyms: REGN-668, SAR-231893 Cat.No.A2038 Purity:99.32%

Dupilumab (anti-IL-4Rα) is a fully human anti–interleukin-4 receptor α monoclonal antibody that inhibits both interleukin-4 (IL-4) and interleukin-13 (IL-13) signalling through blockade of the shared IL-4α subunit.

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1 Citation

17 Nobel Prize winners
have used Selleck products

Shimon Sakaguchi

Nature Communications 2025;16, Article number:1325

David Baker

Dev Cell 2023;58(20):2163-2180.e9.

Michael Houghton

Cell Chem Biol 2020;27(7):780-792.e5

David Julius

Cell 2017;185-198.e16

Charles M. Rice

Cell 2018;172(3):423-438.e25

Quality Control

Batch: Purity: 99.32% Protein concentration: 5.72 mg/ml Endotoxin Level: <1 EU/mg

99.32

Specificity

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Dupilumab (anti-IL-4Rα) is a fully human anti–interleukin-4 receptor α monoclonal antibody that inhibits both interleukin-4 (IL-4) and interleukin-13 (IL-13) signalling through blockade of the shared IL-4α subunit.
References	[1] https://pubmed.ncbi.nlm.nih.gov/29782217/ [2] https://pubmed.ncbi.nlm.nih.gov/29471919/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1190264-60-8
Molecular Weight	147 KD
Isotype	Human IgG4, κ
Source	CHO cells
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20 mM Arg, pH5.0
Storage	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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