Eldelumab (Anti-CXCL10 / IP-10)
Synonyms: BMS-936557; MDX-1100
Eldelumab (Anti-CXCL10 / IP-10) is a humanised monoclonal antibody (IgG1 type) targeting CXCL10. Eldelumab selectively binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab can be used in studies of autoimmune and auto-inflammatory diseases such as rheumatoid arthritis, ulcerative colitis and crohn's disease. MW: 145.5 KD.
Quality Control
Specificity
| Name | Citation | CXCR1 | CXCR2 | CXCR4 | Others |
|---|---|---|---|---|---|
| WZ811 | 20 | ||||
| SB 225002 | 91 | ||||
| Reparixin (Repertaxin) | 24 | CXCL8 | |||
| AMD3465 hexahydrobromide | 1 |
2. "✔" indicates inhibitory effect, but without specific value.
Mechanism of Action
| Description |
Eldelumab (Anti-CXCL10 / IP-10) is a humanised monoclonal antibody (IgG1 type) targeting CXCL10. Eldelumab selectively binds to CXCL10 and blocks CXCL10-induced calcium flux and cell migration. Eldelumab can be used in studies of autoimmune and auto-inflammatory diseases such as rheumatoid arthritis, ulcerative colitis and crohn's disease. MW: 145.5 KD.
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Product Details
| CAS No. | 946414-98-8 |
|---|---|
| Molecular Weight | 145.5 kDa |
| Isotype | Human IgG1 |
| Source | CHO |
| Purification | AKTA |
| Sterility | 0.2 μM filtered |
| Formulation | 100 mM Pro-Ac, 20mM Arg, pH5.0 |
| Storage | Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. |
Comparison of Clones for
*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)
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