Evolocumab (anti-PCSK9)
Synonyms: AMG 145
Evolocumab (anti-PCSK9) is a human monoclonal antibody that inhibits PCSK9. Evolocumab binds to the circulating PCSK9 protein, inhibiting it from binding to the LDLR. Evolocumab can be used for the research of hypercholesterolaemia and atherosclerotic cardiovascular diseases.
3 Citations
17 Nobel Prize winners
have used Selleck products
Shimon Sakaguchi
Nature Communications 2025;16, Article number:1325
David Baker
Dev Cell 2023;58(20):2163-2180.e9.
Michael Houghton
Cell Chem Biol 2020;27(7):780-792.e5
David Julius
Cell 2017;185-198.e16
Charles M. Rice
Cell 2018;172(3):423-438.e25
Quality Control
Specificity
2. "✔" indicates inhibitory effect, but without specific value.
Mechanism of Action
| Description |
Evolocumab (anti-PCSK9) is a human monoclonal antibody that inhibits PCSK9. Evolocumab binds to the circulating PCSK9 protein, inhibiting it from binding to the LDLR. Evolocumab can be used for the research of hypercholesterolaemia and atherosclerotic cardiovascular diseases.
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References |
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Product Details
| CAS No. | 1256937-27-5 |
|---|---|
| Molecular Weight | 141.8 KD |
| Isotype | Human IgG2 |
| Application | Evolocumab (anti-PCSK9) |
| Sterility | 0.2 μM filtered |
| Formulation | PBS Buffer, PH 7.4 |
| Storage | Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles. |
Comparison of Clones for
*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)
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