For research use only. Not for use in humans.

Fresolimumab (Anti-TGFb1)

Synonyms: GC1008 Cat.No.A2336 Purity:99%

Fresolimumab (Anti-TGFb1) is a pan-specific, recombinant, fully human monoclonal antibody directed against human transforming growth factor (TGF) beta 1, 2, and 3 with potential antineoplastic activity. MW : 145.5 KD.

Quality Control

Batch: Purity: 99% Protein concentration: 3.85mg/ml Endotoxin Level: ＜1EU/mg

Specificity

Name	Citation	ALK1	ALK2	ALK3	ALK4	TGFβRI/ALK5	ALK6	TGFβRII	TGF-β	Smad3	Others
SB431542	799					+
LDN-193189	262	++++	++++	+++			+++
Galunisertib (LY2157299)	192					++
LY2109761	137					++		+
SB-525334	116					+++
SB505124	37				+	++
GW788388	25					+++
LY364947	49					++		+			RIPK2,CK1δ,MLK-7K
RepSox (E-616452)	82					++++
LDN-193189 Dihydrochloride	103	++++	++++	+++			+++
K02288	24	++++	++++	++			+++
LDN-214117	4		++
SD-208	21					++
Vactosertib (TEW-7197)	28				+++	+++
ML347	5	++	++
LDN-212854	7	++++	++++	+	+	+
DMH1	61		+
Alantolactone	3									✔	STAT3
SIS3 Hydrochloride	85									✔
Hesperetin	4								✔		Histamine receptor

Expand to Check More

1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Fresolimumab (Anti-TGFb1) is a pan-specific, recombinant, fully human monoclonal antibody directed against human transforming growth factor (TGF) beta 1, 2, and 3 with potential antineoplastic activity. MW : 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	948564-73-6
Molecular Weight	145.5 kDa
Isotype	Human IgG4SP
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.