Glembatumumab vedotin
Synonyms: CDX-011 (DOX), CR011,CR011-vcMMAE
Glembatumumab vedotin (CDX-011 (DOX), CR011, CR011-vcMMAE) is an antibody-drug conjugate (ADC) composed of a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB), conjugated to Monomethyl Auristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker. Glembatumumab vedotin has the potential for use in research of Breast cancer (TNBC) and advanced or metastatic melanoma.
CAS No. 1182215-65-1
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Mechanism of Action
| Description |
Glembatumumab vedotin (CDX-011 (DOX), CR011, CR011-vcMMAE) is an antibody-drug conjugate (ADC) composed of a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB), conjugated to Monomethyl Auristatin E (MMAE), via a cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker. Glembatumumab vedotin has the potential for use in research of Breast cancer (TNBC) and advanced or metastatic melanoma.
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Product Details
| CAS No. | 1182215-65-1 |
|---|---|
| ADC antibody | Glembatumumab |
| ADC cytotoxin | MMAE |
| Formulation | 1xPBS |
| Storage | Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles. |
Comparison of Clones for
*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)
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