For research use only. Not for use in humans.

Lonigutamab (Anti-IGF1R / CD221)

Synonyms: null Cat.No.A2926

Lonigutamab (hz208F2-4) is a humanised monoclonal antibody against the insulin-like growth factor-1 receptor (IGF-1R) with the potential to treat thyroid eye disease (TED). MW: 146.26 KD.

Quality Control

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SDS
Datasheet

Specificity

Name	Citation	IGF-1R	Insulin Receptor	Others
Linsitinib (OSI-906)	206	+++	++	IRR
NVP-AEW541	65	++	++	FLT3,Tek,FLT1
GSK1904529A	26	+++	+++
NVP-ADW742	24	+
BMS-536924	26	++	+++	FAK,MEK,LCK
AG-1024	27	+	+
GSK1838705A	18	+++	++++	ALK
BMS-754807	54	++++	++++	TrkB,Met,TrkA
PQ 401	3	+
Picropodophyllin (AXL1717)	48	++++

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Lonigutamab (hz208F2-4) is a humanised monoclonal antibody against the insulin-like growth factor-1 receptor (IGF-1R) with the potential to treat thyroid eye disease (TED). MW: 146.26 KD.
References	[1] https://pubmed.ncbi.nlm.nih.gov/36556449/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	2362015-67-4
Molecular Weight	146.26
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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