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LY2119620 AChR agonist

Name: LY2119620
Brand: Selleck Chemicals
SKU: S7366
Rating: 5 (1 reviews)

Cat.No.S7366

LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.

Chemical Structure

Molecular Weight: 437.94

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Quality Control

Batch: S736601 DMSO]87 mg/mL]false]Ethanol]10 mg/mL]false]Water]Insoluble]false Purity: 99.81%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS
Datasheet

99.81

Related Targets	Adrenergic Receptor 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other AChR Inhibitors	PNU-120596 Benzethonium Chloride Arecoline HBr Lycorine Otilonium Bromide (-)-Huperzine A (HupA) Hyoscyamine Cytisine Nitenpyram Palmatine

Chemical Information, Storage & Stability

Molecular Weight	437.94	Formula	C₁₉H₂₄ClN₅O₃S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	886047-22-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CC1=C2C(=C(SC2=NC(=C1Cl)OCC(=O)N3CCN(CC3)C)C(=O)NC4CC4)N

Solubility

In vitro
Batch:

DMSO : 87 mg/mL (198.65 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 10 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
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Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	M2 muscarinic acetylcholine receptor M4 muscarinic acetylcholine receptor
In vitro	LY2119620 displays modest allosteric agonism and positively modulates the functional G protein–signalling ability of an agonist at the M2/M4 receptor subtypes by placing the M2 and M4 receptors into an active G protein–bound state. This compound enhances the potency of three muscarinic acetylcholine receptor agonists, ACh, Oxo-M and iperoxo. [³H]this chemical can be used as a probe for the human M(2) and M(4) muscarinic receptor allosteric binding sites.
References	[1] https://pubmed.ncbi.nlm.nih.gov/24807965/ [2] https://pubmed.ncbi.nlm.nih.gov/24807966/

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