Name: Mepivacaine HCl
Brand: Selleck Chemicals
SKU: S3155
Rating: 5 (1 reviews)

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Quality Control

Batch: S315501 Water]57 mg/mL]false]Ethanol]8 mg/mL]false]DMSO]3 mg/mL]false Purity: 99.90%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS
Datasheet

99.90

Related Targets	CFTR CRM1 CD markers AChR Calcium Channel Potassium Channel GABA Receptor TRP Channel ATPase GluR
Other Sodium Channel Inhibitors	Camostat Mesilate A-803467 cariporide Tolperisone HCl Vinpocetine Veratramine Bulleyaconi cine A Ambroxol HCl Benzocaine Nefopam HCl

Chemical Information, Storage & Stability

Molecular Weight	282.81	Formula	C₁₅H₂₂N₂O.HCl	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	1722-62-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C.Cl

Solubility

In vitro
Batch:

Water : 57 mg/mL

Ethanol : 8 mg/mL

DMSO : 3 mg/mL (10.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vivo

The tests made in horse show greater diffusion of Mepivacaine between adjacent synovial structures than assumed from previous anatomical, latex injection and contrast arthrographic studies. Ultrasound provides a 37% reduction in the minimum effective anesthetic volume (MEAV50) of 1.5% Mepivacaine required to block the sciatic nerve compared with neurostimulation in patients undergoing knee arthroscopy. The use of 3% Mepivacaine provides a shorter duration of anesthesia than the lidocaine formulations with epinephrine in the canines and premolars.

References

[1] https://pubmed.ncbi.nlm.nih.gov/11817556/
[2] https://pubmed.ncbi.nlm.nih.gov/19843807/
[3] https://pubmed.ncbi.nlm.nih.gov/19840637/

[4] https://pubmed.ncbi.nlm.nih.gov/1606097/
[5] https://pubmed.ncbi.nlm.nih.gov/10195537/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04257682	Not yet recruiting	Knee Osteoarthritis\|Hip Osteoarthritis	Ottawa Hospital Research Institute	September 2022	Phase 4
NCT01533545	Terminated	Renal Insufficiency Chronic	Rigshospitalet Denmark	September 2012	Not Applicable
NCT01032798	Completed	Local Anesthetic Effectiveness	University of Campinas Brazil\|Fundação de Amparo à Pesquisa do Estado de São Paulo	May 2007	Phase 1

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Mepivacaine HCl Sodium Channel inhibitor

Chemical Structure

Molecular Weight: 282.81