Home Metabolism PPAR activator Phytol

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Phytol PPAR activator

Cat.No.S5121

Phytol (Trans-Phytol), a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.
Phytol PPAR activator Chemical Structure

Chemical Structure

Molecular Weight: 296.53

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Quality Control

Batch: S512101 Purity: 98%
98

Chemical Information, Storage & Stability

Molecular Weight 296.53 Formula

C20H40O

 Storage (From the date of receipt) 2 years  -20°C  liquid
CAS No. 150-86-7 -- Storage of Stock Solutions

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Mechanism of Action

Targets/IC50/Ki
PPARα
In vitro
Phytol, a branched-chain fatty alcohol, is the naturally occurring precursor of phytanic and pristanic acid, branched-chain fatty acids that are both ligands for the nuclear hormone receptor peroxisome proliferator-activated receptor α (PPARα). The addition of this compound upregulates the expression of PPARα-target genes at both mRNA and protein levels in PPARα-expressing HepG2 hepatocytes. It is a specific ligand for PPARα, although it can activate PPARγ moderately. In vitro, this chemical reduces the motor activity of worms and causes their death. Additionally, it at sublethal doses (25 µg/mL) reduces the number of Schistosoma mansoni eggs.
In vivo
In many animal studies, Phytol is used as a precursor of phytanic acid. Addition of this compound to the diet results in an increase of Phytol Metabolites in tissues and plasma. In vivo, a single dose of this chemical (40 mg/kg) administered orally to mice infected with adult S. mansoni results in total and female worm burden reductions of 51.2% and 70.3%, respectively. Moreover, it reduces the number of eggs in faeces (76.6%) and the frequency of immature eggs (oogram pattern) is significantly reduced. In medicinal fields, this compound has shown antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is an excellent immunostimulant, superior to a number of commercial adjuvants in terms of long-term memory induction and activation of both innate and acquired immunity.
References
  • [4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3879229/

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