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Ro 48-8071 fumarate

Name: Ro 48-8071 fumarate
Brand: Selleck Chemicals
SKU: E8319
Rating: 5 (1 reviews)

Cat.No.E8319

Ro 48-8071 fumarate is a potent, selective inhibitor of 2,3-oxidosqualene cyclase (OSC) (IC50 = 6.5 nM), a key enzyme downstream of HMG-CoA reductase that catalyses lanosterol formation in cholesterol biosynthesis. It reduces intracellular cholesterol levels without the feedback upregulation of HMG-CoA reductase seen with statins, providing a distinct, self-limiting regulatory loop for lowering LDL-C. Additionally, it also exhibits significant anti-cancer properties by inducing apoptosis and disrupting cell signalling in cancer models.

Chemical Structure

Molecular Weight: 564.44

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Cited in Nature Medicine for its top-tier quality
SDS
Datasheet

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other Others Inhibitors	Furimazine (PBI 3939) BAY 2927088（Sevabertinib） Guanidinoacetic acid BAPTA-AM Blebbistatin Silibinin (NSC 651520) Polybrene (Hexadimethrine Bromide) Carbazochrome sodium sulfonate (AC-17) Palmitic acid Ursolic Acid

Chemical Information, Storage & Stability

Molecular Weight	564.44	Formula	C₂₃H₂₇BrFNO₂.C₄H₄O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	189197-69-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

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Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/9162756/

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