For research use only. Not for use in humans.

Sabatolimab (anti-TIM-3)

Synonyms: MBG453, NVP-MBG453 Cat.No.A2037 Purity:99.44%

Sabatolimab (anti-TIM-3) (MBG453, NVP-MBG453) is a high-affinity, humanised IgG4 antibody targeting TIM-3 on the surface of T-cells.

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3 Citations

17 Nobel Prize winners
have used Selleck products

Shimon Sakaguchi

Nature Communications 2025;16, Article number:1325

David Baker

Dev Cell 2023;58(20):2163-2180.e9.

Michael Houghton

Cell Chem Biol 2020;27(7):780-792.e5

David Julius

Cell 2017;185-198.e16

Charles M. Rice

Cell 2018;172(3):423-438.e25

Quality Control

Batch: Purity: 99.44% Protein concentration: 6.3mg/ml Endotoxin Level: ＜1EU/mg

99.44

Specificity

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Sabatolimab (anti-TIM-3) (MBG453, NVP-MBG453) is a high-affinity, humanised IgG4 antibody targeting TIM-3 on the surface of T-cells.
References	[1] https://ashpublications.org/blood/article/136/Supplement%201/1/470443/Efficacy-and-Safety-of-Sabatolimab-MBG453-in

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	2252262-24-9
Molecular Weight	145 KD
Isotype	Human IgG4, κ
Application	Sabatolimab (anti-TIM-3)
Source	CHO cells
Purification	Protein G
Sterility	0.2 μM filtered
Formulation	PBS Buffer, PH 7.4
Storage	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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