Sarilumab (anti-IL-6Rα)

Sarilumab (anti-IL-6Rα) is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.

Sarilumab (anti-IL-6Rα) Chemical Structure

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6 Citations

17 Nobel Prize winners
have used Selleck products

Shimon Sakaguchi

Nature Communications 2025;16, Article number:1325

David Baker

Dev Cell 2023;58(20):2163-2180.e9.

Michael Houghton

Cell Chem Biol 2020;27(7):780-792.e5

David Julius

Cell 2017;185-198.e16

Charles M. Rice

Cell 2018;172(3):423-438.e25

Quality Control

Batch: A201101 Purity: 98.05% Protein concentration: 5.0 mg/ml Endotoxin Level: ≤1 EU/mg

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

98.05

Specificity

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Sarilumab (anti-IL-6Rα) is a fully human anti-IL-6Rα mAb that binds membrane-bound and soluble human IL-6Rα with high affinity, MW: 144.13 KD.
Features	Human IgG1
Targets/IC₅₀/Ki	IL-6R (human) 61.9 pM(Kd) IL-6R (monkey) 71.9 pM(Kd)
In vitro	Sarilumab can reverse IL-6 enhanced colony formation in HCC cells under sorafenib or regorafenib treatment.
Cell Research	Cells were treated with drugs for 36 h. The soluble form of IL-6Rα in cell culture supernatants was measured with a human IL-6Rα ELISA kit according to the manufacturer’s instructions. Plates were measured on a microplate reader at a wavelength of 450 nm.
In vivo	Sarilumab has been shown in preclinical studies to inhibit IL-6 signalling in a dose-dependent manner.
References	[1] https://pubmed.ncbi.nlm.nih.gov/34687791/ [2] https://pubmed.ncbi.nlm.nih.gov/24297381/

Product Details

CAS No.	1189541-98-7
Isotype	Human IgG1
Source	CHO cells
Sterility	0.2 μM filtered
Formulation	PBS buffer, pH 7.2
Storage	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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Frequently Asked Questions

Question 1:
How to store the antibody?

Answer:
Store the undiluted solution at 4 °C in the dark. Freezing antibodies can result in a loss of activity caused by the freezing/thawing process. Diluting antibodies to working concentrations and storing at 4°C for more than a day should be avoided. Additionally, make sure to keep the antibody sterile. Under these storage conditions, your antibodies should remain active for up to one year and oftentimes longer.