Secukinumab (anti-IL-17A)

Secukinumab (anti-IL-17A) (AIN457) is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is applied for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. MW=147.9 kDa.

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3 Citations

17 Nobel Prize winners
have used Selleck products

Shimon Sakaguchi

Nature Communications 2025;16, Article number:1325

David Baker

Dev Cell 2023;58(20):2163-2180.e9.

Michael Houghton

Cell Chem Biol 2020;27(7):780-792.e5

David Julius

Cell 2017;185-198.e16

Charles M. Rice

Cell 2018;172(3):423-438.e25

Quality Control

Batch: A202501 Purity: 99.82% Protein concentration: 5.00mg/ml Endotoxin Level: <1EU/mg

Cited in Nature Medicine for its top-tier quality
COA
SDS
Datasheet

99.82

Specificity

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Secukinumab (anti-IL-17A) (AIN457) is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is applied for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. MW=147.9 kDa.
In vitro	Secukinumab can reduce cell growth in the miR130b-knockdown OCI-ly10 co-culture system.
Cell Research	MTT assay was adopted to measure cell growth in the control inhibitor or miR130b inhibitor transfected OCI-ly10 co-culture system upon treatment with or without IL17 inhibitor.
In vivo	Secukinumab administration significantly attenuates AAV8-IRF8 mediated recruitment of neutrophils, also downregulates the autophagy level and inhibits the release of either autophagy-dependent or independent chemokines in vivo.
Animal Research	Animal Models: C57BL/6 mice, IRF8 FLOX mice (C57BL/6J background) Dosages: 200 μg Administration: i.p. Reference: https://pubmed.ncbi.nlm.nih.gov/34400126/
References	[1] https://pubmed.ncbi.nlm.nih.gov/35301282/ [2] https://pubmed.ncbi.nlm.nih.gov/34400126/

Product Details

CAS No.	1229022-83-6
Isotype	Human IgG1
Source	Human
Sterility	0.2 μM filtered
Formulation	PBS buffer, pH 7.2
Storage	Store the undiluted solution at 4°C in the dark to avoid freeze-thaw cycles

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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