For research use only. Not for use in humans.

Spesolimab (Anti-IL-1RL2 / IL-36R)

Synonyms: BI 655130 Cat.No.A2442 Purity:99%

Spesolimab (Anti-IL-1RL2 / IL-36R) is a humanised antagonistic monoclonal antibody targeting the IL-36 receptor. It can be used for the treatment of palmoplantar pustulosis (PPP) and generalised pustular psoriasis (GPP). MW: 145.5 KD.

Quality Control

Batch: A244201 Purity: 99% Protein concentration: 4.09mg/ml Endotoxin Level: ＜1EU/mg

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COA
SDS
Datasheet

Specificity

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Spesolimab (Anti-IL-1RL2 / IL-36R) is a humanised antagonistic monoclonal antibody targeting the IL-36 receptor. It can be used for the treatment of palmoplantar pustulosis (PPP) and generalised pustular psoriasis (GPP). MW: 145.5 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	2097104-58-8
Molecular Weight	145.5 kDa
Isotype	Human IgG1
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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