For research use only. Not for use in humans.

Ulocuplumab (Anti-CXCR4 / CD184)

Synonyms: BMS 936564; MDX 1338; Anti-Human CXCR4 Recombinant Antibody Cat.No.A2523 Purity:99%

Ulocuplumab (Anti-CXCR4 / CD184) is a fully human IgG4 antibody, targeting CXCR4. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukaemia (CLL). Ulocuplumab exhibits antitumor activity in established tumours including acute myeloid leukaemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models. MW: 144.84 KD.

Quality Control

Batch: A252301 Purity: 99% Protein concentration: 6.72mg/ml Endotoxin Level: ＜1EU/mg

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COA
SDS
Datasheet

Specificity

Name	Citation	CXCR1	CXCR2	CXCR4	Others
WZ811	20			++++
SB 225002	91		+++
Reparixin (Repertaxin)	24	✔			CXCL8
AMD3465 hexahydrobromide	1			✔

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Ulocuplumab (Anti-CXCR4 / CD184) is a fully human IgG4 antibody, targeting CXCR4. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukaemia (CLL). Ulocuplumab exhibits antitumor activity in established tumours including acute myeloid leukaemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models. MW: 144.84 KD.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1375830-34-4
Molecular Weight	144.84 kDa
Isotype	Human IgG4SP
Source	CHO
Purification	AKTA
Sterility	0.2 μM filtered
Formulation	100 mM Pro-Ac, 20mM Arg, pH5.0
Storage	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Sellecks selected clones are more frequently applied. (data until September 2024)

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