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PARP2-Selective Inhibitors

  • PARP1
  • PARP2
  • PARP3
  • Tankyrase-1
Cat.No. Product Name Information Selective / Pan IC50 / Ki
S8038 UPF 1069 UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM. It is ~27-fold selective against PARP1. Selective PARP2, IC50: 0.3 μM
S1060 Olaparib (AZD2281, Ku-0059436) Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM, 300-times less effective against tankyrase-1. Phase 3. Pan PARP2, IC50: 1 nM
S2197 A-966492 A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. Pan PARP2, Ki: 1.5 nM
S1004 Veliparib (ABT-888) Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively. It is inactive to SIRT2. Phase 3. Pan PARP2, Ki: 2.9 nM