CFTR Activators

Featured Inhibitors
Inhibitors (6)
Modulators (6)
Chemical (1)
Activators (2)

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S8698	GLPG1837	GLPG1837 (ABBV-974) is a novel CFTR potentiator with an EC50 value of 3 nM for F508del, showing enhanced efficacy on CFTR mutants harboring class III mutations compared to Ivacaftor.	Cell Mol Life Sci, 2024, 81(1):426 iScience, 2022, 25(1):103710 Int J Mol Sci, 2022, 23(18)10758
S6911	Nesolicaftor (PTI-428)	Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S8698

GLPG1837

GLPG1837 (ABBV-974) is a novel CFTR potentiator with an EC50 value of 3 nM for F508del, showing enhanced efficacy on CFTR mutants harboring class III mutations compared to Ivacaftor.

Cell Mol Life Sci, 2024, 81(1):426

iScience, 2022, 25(1):103710

Int J Mol Sci, 2022, 23(18)10758

S6911

Nesolicaftor (PTI-428)

Nesolicaftor (PTI-428) is a specific cystic fibrosis transmembrane conductance regulator (CFTR) amplifier that increases CFTR expression.