Decarboxylase Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S4582	Eflornithine (DFMO) Hydrochloride Hydrate	Eflornithine (DFMO) hydrochloride hydrate inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis. Its biological half-life is 8 hours.	Cancer Lett, 2025, 630:217887 Front Oncol, 2023, 13:1212604 mBio, 2022, 13(5):e0219422
S2453	Benserazide HCl	Benserazide HCl (Ro-4-4602) is a peripherally-acting aromatic L-amino acid Decarboxylase (AAAD) or DOPA Decarboxylase inhibitor.Solutions are unstable and should be fresh-prepared.	Front Pharmacol, 2024, 15:1404532 Viruses, 2024, 16(10)1566 Elife, 2022, 11e72668
S1891	Carbidopa	Carbidopa is an aromatic-L-amino-acid Decarboxylase inhibitor with an IC50 of 29 ± 2 μM.	Signal Transduct Target Ther, 2021, 6(1):77 J Cell Physiol, 2021, 10.1002/jcp.30587 PLoS One, 2017, 12(3):e0173240
S1642	Methyldopa	Methyldopa (Aldomet) is a DOPA decarboxylase competitive inhibitor with an ED50 of 21.8 mg/kg.	J Immunother Cancer, 2024, 12(11)e009805
E8286^New	Ivospemin	Ivospemin is a spermine analogue and polyamine inhibitor that lowers polyamine levels by inhibiting the activity of the polyamine biosynthetic enzyme ornithine decarboxylase (ODC) in cancer cell lines. It shows potential as a treatment for metastatic pancreatic adenocarcinoma.
S3086	Maleic acid	Maleic acid inhibits glutamate Decarboxylase (GAD) activity, thus enhances acid sensitivity of Listeria monocytogenes. This compound affects the extracellular GABA levels.
E0654	D-Arginine	D-Arginine is an inhibitor of arginine decarboxylase(ADC) to regulate putrescine biosynthesis.
S5448	S(-)-Carbidopa	S(-)-Carbidopa is a peripheral decarboxylase inhibitor, used in combination with levodopa for treatment of Parkinsonism.
E1189	TES-1025	TES-1025 is a potent and selective human α-amino-β-carboxymuconate-ε-semialdehyde decarboxylase (ACMSD) inhibitor with an IC50 of 13 nM.
S5444	4-Bromo-3-hydroxybenzoic acid	4-bromo-3-hydroxybenzoic acid is a potent inhibitor of the enzyme histidine decarboxylase with resultant inhibition of histamine formation in mammals.
S5409	Chelidamic acid hydrate	Chelidamic acid is a pharmaceutical intermediate as well as a cosmetic material due to its anti-inflammatory and whitening effect. Chelidamic acid is also one of the most potent inhibitors of glutamate Decarboxylase, with a Ki of 33 μM.
E7388	(S)-2-Allylglycine	(S)-2-Allylglycine (L-Allylglycine) is a potent inhibitor of glutamic acid Decarboxylase (GAD), the key enzyme in GABA biosynthesis, causing GABA depletion, seizures, and neuronal damage. It is used in research on treatment-resistant seizures in epilepsy.
S0108	AZ-33	AZ-33 (LDHA Inhibitor 33) is a potent inhibitor of lactate dehydrogenase A (LDHA) with an IC50 of 0.5 μM. LDHA is the key enzyme involved in anaerobic glycolysis which is frequently deregulated in human malignancies.	FASEB J, 2022, 36(3):e22229 Front Mol Biosci, 2021, 8:806650
S5579	Chelidonic acid	Chelidonic acid (Jerva acid, Jervaic acid, γ-Pyrone-2,6-dicarboxyl acid) is a secondary metabolite found in several plants with therapeutic potential in allergic disorders in experimental animals. This compound inhibits IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. It is also an inhibitor of glutamate decarboxylase with Ki of 1.2 μM.