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GABA Receptor Modulators

Cat.No. Product Name Information Product Use Citations Product Validations
S6611 Cyclothiazide Cyclothiazide is a positive allosteric modulator of ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors with critical roles in neurological development and function.
J Clin Invest, 2025, 135(24)e191772
Nucleic Acids Res, 2025, 53(18)gkaf965
Nucleic Acids Res, 2024, gkae761
S5131 Homotaurine Homotaurine (Tramiprosate, Alzhemed, 3-Amino-1-propanesulfonic acid) is a synthetic organic compound that has GABAergic activity by mimicking GABA. It is a GABAA partial agonist as well as a GABAB receptor partial agonist with low efficacy.
S3959 (+)-Borneol (+)-Borneol is one of enantiomers of borneol which is a valuable medical material, senior aromatic spice, and chemical material and has been used in food and also folk medicine.
S5596 (1S)-(-)-α-Pinene α-Pinene is found in the oils of many species of many coniferous trees, notably the pine and has insecticidal activity. (1S)-(-)-α-Pinene is a monoterpene and shows sleep enhancing property through a direct binding to GABAA-benzodiazepine (BZD) receptors by acting as a partial modulator at the BZD binding site.
E0101 AZD6280 AZD6280 is a selective GABAA (α2/3) receptor modulator, used for treatment of generalized anxiety disorder.
E7965New (2S)-6-Prenylnaringenin (2S)-6-Prenylnaringenin demonstrates the highest efficacy among tested compounds in the forebrain. This compound functions as a positive allosteric modulator of GABAA receptors at the α+β- binding interface.
S0164 AZD7325 AZD7325 is a potent and orally active partial selective Positive allosteric modulator (PAM) of GABAAα2 and Aα3 receptor with Ki=0.3 and 1.3 nM, respectively, and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes.
S9409 Kavain Kavain ((+)-Kavain), the main kavalactone found mostly in the roots of the kava plant, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. This compound positively modulated the γ-Aminobutyric acid type A (GABAA) receptor.
S3977 (-)-Borneol (-)-Borneol (L-Borneol), one of enantiomers of borneol, has a camphoraceous and evident woody odour. This compound has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.
S6755 NS 11394 NS11394 is a subtype-selective positive allosteric modulator at GABAA receptors, with selectivity for the α3 and α5 subtypes.
E0960 RO5186582 RO5186582 (Basmisanil, RG1662) is a highly selective GABAAα5 negative allosteric modulator.