Integrase Inhibitors
| Cat.No. | Product Name | Information | Product Use Citations | Product Validations |
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| S2005 | Raltegravir | Raltegravir is a potent integrase (IN)<> inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. It shows greater than 1000-fold selectivity for HIV-1 IN over several related Mg2+-dependent enzyme such as HCV polymerase, HIV reverse transcriptase, HIV RNaseH and human -, -, -polymerases. |
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| S2001 | Elvitegravir | Elvitegravir is an HIV Integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM in cell-free assays, respectively. |
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| S2667 | GSK1349572 (Dolutegravir) | Dolutegravir is a two-metal-binding HIV integrase inhibitor with an IC50 of 2.7 nM in a cell-free assay, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. |
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| S7766 | GSK1265744 (Cabotegravir) | Cabotegravir (GSK744, GSK1265744, S/GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalysed strand transfer reaction with IC50 of 3.0 nM. Phase 2. |
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| S5245 | Raltegravir potassium | Raltegravir potassium(MK-0518 potassium) is the orally bioavailable potassium salt of Raltegravir, the first approved human immunodeficiency virus type 1 (HIV-1) Integrase inhibitor. |
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| S4642 | Dolutegravir Sodium | Dolutegravir Sodium (GSK-1349572A) is an HIV Integrase inhibitor with IC50 of 2.7 nM. |
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| S2765 | MK-2048 | MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively. |
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| S5911 | Bictegravir | Bictegravir (GS-9883) is a novel, potent, once-daily, unboosted inhibitor of HIV-1 integrase. |
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| S1366 | BMS-707035 | BMS-707035 is a specific HIV-I Integrase (IN) inhibitor with an IC50 of 15 nM. Phase 2. |
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| E0161 | Bictegravir Sodium |
Bictegravir (GS-9883) Sodium is a novel and potent inhibitor of HIV-1 integrase, specifically targets IN strand transfer activity with an IC50 of 7.5 nM. |
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| E0459 | Robinetin | Robinetin inhibits HIV integrase cleavage and integration in a dose-dependent manner, inhibits the DNA synthesis in Proteus vulgaris, and the RNA synthesis in S. aureus, also inhibits egg yolk phosphatidylcholine (EYPC) membrane lipid peroxidation and hemoglobin A (HbA) glycosylation with high efficiency. | ||
| E4468 | Cabotegravir Sodium | Cabotegravir (GSK-1265744) sodium is an orally active and long-acting HIV integrase strand transfer inhibitor. It also inhibits organic anion transporter 1/3 (OAT1/OAT3) with IC50 of 0.41 μM and 0.81 μM for OAT3 and OAT1, respectively. | ||
| S0235 | Lavendustin B | Lavendustin B inhibits HIV-1 Integrase (IN) interaction with its cognate cellular cofactor lens epithelium-derived growth factor (LEDGF/p75). This compound is an inhibitor of Tyrosine Kinase and also a competitive inhibitor of glucose transporter 1 (Glut1). | ||
| S4187 | Salicylanilide | Salicylanilides (WR10019,2-Hydroxybenzanilide) are a group of compounds with a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities. |
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