Chloride Channel Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S1698	Torsemide	Torsemide (AC-4464, JDL-464) is a pyridyl sulfonylurea with a chemical structure between that of traditional loop diuretics and Cl- channel blockers, used to treat hypertension.	J Immunother Cancer, 2024, 12(11)e009805 Cell Chem Biol, 2021, S2451-9456(21)00442-6
S0454	Adjudin	Adjudin (AF-2364), a potent male contraceptive, is a potent blocker of Cl⁻ channels. This compound exhibits anti-inflammatory properties by suppression of NF-κB p65 nuclear translocation and DNA binding activity as well as ERK MAPK phosphorylation.	Brain Res Bull, 2022, 182:80-89
E4665^New	NMD670	NMD670 is a first-in-class small molecule inhibitor of skeletal muscle-specific chloride channel (ClC-1) with an EC50 of 1.6 μM. It improves muscle weakness and fatigue in neuromuscular diseases and may serve as a potential therapeutic approach for Myasthenia Gravis (MG).
E7830	R(+)-Methylindazone	R(+)-Methylindazone (R(+)-IAA-94) is a potent and specific indanyloxyacetic inhibitor of the renal epithelial chloride channel and exacerbates myocardial infarction by impairing mitochondrial calcium retention capacity (CRC), leading to mitochondrial permeability transition pore (mPTP) opening and increased cell death during ischaemia-reperfusion injury.
S3264	Atractyloside potassium salt	Atractyloside potassium salt (ATR potassium salt), a toxic diterpenoid glycoside isolated from the fruits of Xanthium sibiricum (Cang'erzi), is a powerful and specific inhibitor of mitochondrial ADP/ATP carriers. This compound inhibits chloride channels from mitochondrial membranes of rat heart.
S0125	CaCCinh-A01	CaCCinh-A01 (TMEM16 Blocker I) is a blocker of TMEM16A with an IC50 of 2.1 μM. This compound is also an inhibitor of calcium-activated Chloride Channel (CaCC) with an IC50 of ~ 10 μM.
S3807	Dehydroandrographolide	Dehydroandrographolide, isolated from Andrographis paniculata (Burm. F.) Nees (Chuan-xin-lian), is a novel TMEM16A inhibitor and possesses multiple pharmacological activities, including anti-inflammation, anti-cancer, anti-bacterial, anti-virus and anti-hepatitis activity.
S2955	NS1652	NS1652 is a reversible Chloride Channel blocker, potently inhibits the chloride conductance (IC50 = 1.6 µM) in human and mouse red blood cells, but only weakly volume activated anion conductance (VRAC) (IC50 = 125 µM) in HEK293 cells.
S1203	T16Ainh-A01	T16Ainh-A01 is a potent and selective inhibitor of calcium-activated chloride channel (CaCC)/transmembrane protein 16A (TMEM16A, ANO1) with an IC50 of 1.8 μM.
S8279	(±)-Shikonin	(±)-Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.	Signal Transduct Target Ther, 2025, 10(1):341 J Exp Clin Cancer Res, 2025, 44(1):299 Free Radic Biol Med, 2025, 237:65-75
S6439	Talniflumate	Talniflumate (MSI-1995) is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. This compound is also an inhibitor of human calcium-activated Chloride Channel.	Toxicol Lett, 2025, 406:31-37 Acta Pharm Sin B, 2023, 13(2):662-677
S4339	Meticrane	Meticrane is a diuretic that inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule. This compound is used to treat essential hypertension.
S6470	Fluralaner	Fluralaner (A1443, AH252723) is a systemic insecticide and acaricide that is administered orally. This compound inhibits γ-aminobutyric acid (GABA)-gated Chloride Channel (GABAA receptors) and L-glutamate-gated Chloride Channel (GluCls)