Glucocorticoid Receptor Inhibitors

Cat.No.	Product Name	Information	Product Use Citations
S1628	Triamcinolone Acetonide	Triamcinolone Acetonide is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation. This compound is a synthetic glucocorticoid, used in the symptomatic treatment of inflammation.	Arch Toxicol, 2025, 99(3):1105-1116 FASEB J, 2025, 39(1):e70298 J Transl Med, 2022, 20(1):561
S1992	Fluticasone propionate	Fluticasone Propionate (CCI-187881) is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.	Heliyon, 2024, 10(20):e39475 Cell Rep Methods, 2023, 3(4):100440 Cell Reports Methods, 2023, 10.1016/j.crmeth.2023.100440
S2570	Prednisolone Acetate	Prednisolone Acetate (Omnipred,Prednisolone-21-acetate) is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant agent.	Oncogene, 2024, 43(4):235-247 J Immunotoxicol, 2021, 18(1):154-162 Eur J Rheumatol, 2021, 10.5152/eurjrheum.2021.20054
S1733	Methylprednisolone	Methylprednisolone is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. This compound activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. It markedly reduces autophagy and apoptosis.	Food Chem Toxicol, 2024, 188:114665 Drug Test Anal, 2020, 10.1002/dta.2917 Nat Med, 2017, 23(4):424-428
S2584	Clobetasol propionate	Clobetasol propionate (CGP9555, CCl 4725) is an anti-inflammatory corticosteroid used to treat various skin disorders.	Nat Commun, 2025, 16(1):699 Pharmacol Res, 2025, S1043-6618(25)00049-0 Exp Ther Med, 2019, 18(2):1258-1266
S1933	Triamcinolone	Triamcinolone is a glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated.	bioRxiv, 2025, 2025.08.03.668359 Gastroenterology, 2024, S0016-5085(24)00062-3 Drug Test Anal, 2020, 10.1002/dta.2917
S5685	Desoximetasone	Desoximetasone (Desoxymethasone, Desoximetasonum) is a synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity.	Free Radic Biol Med, 2023, 203:1-10 Cell Death Dis, 2022, 13(6):521 Autophagy, 2021, 10.1080/15548627.2021.2008692
S5489	Prednisone acetate	Prednisone acetate (Betapar, Cortan, Deltasone, Fernisone, Meticorten, Prednisone 21-acetate) is a glucocorticoid steroid that can be used as a glucocorticoid receptor agonist with anti-inflammatory and immunomodulating properties.	Blood Cancer J, 2022, 12(3):36 Front Immunol, 2021, 12:739605 J Immunotoxicol, 2021, 18(1):154-162
S1987	Mometasone furoate	Mometasone Furoate (SCH-32088, mometasone 17-furoate) is a glucocorticoid receptor agonist, used topically to reduce inflammation of the skin or in the airways.	Sci Rep, 2024, 14(1):30786 J Bone Oncol, 2024, 47:100618
S1500	Betamethasone	Betamethasone (NSC-39470, SCH-4831) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.	BMC Pharmacol Toxicol, 2024, 25(1):25 Anticancer Drugs, 2022, 10.1097/CAD.0000000000001344
S4088	Flumethasone	Flumethasone (RS-2177, NSC-54702, Flumetasone) is a Glucocorticoid Receptor agonist, this complex binds to the nucleus causing a variety of genetic activation and repressions.	Elife, 2023, 12e82249 Drug Test Anal, 2020, 10.1002/dta.2917
S1701	Desonide	Desonide is a low potency topical corticosteroid.	Nat Commun, 2022, 13(1):4109 Drug Test Anal, 2020, 10.1002/dta.2917
S5184	Dexamethasone palmitate	Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone (DXM), is a glucocorticoid receptor agonist with a 47-fold lower affinity for the glucocorticoid receptor than DXM. This compound exhibits anti-inflammatory activity.	Dis Model Mech, 2022, dmm.049109 Hematology, 2022, 27(1):32-42
S1669	Loteprednol etabonate	Loteprednol etabonate is a potent glucocorticoid receptor agonist, used in treatment of inflammation of the eye due to allergies.	Int J Biol Macromol, 2025, 306(Pt 3):141644
S1888	Deflazacort	Deflazacort (MDL 458) is a glucocorticoid used as an anti-inflammatory and immunosuppressant.	Drug Test Anal, 2020, 10.1002/dta.2917
S2470	Fluocinolone Acetonide	Fluocinolone Acetonide (Flucort-N) is a corticosteroid that binds to the cytosolic Glucocorticoid Receptor.	Acta Pharm Sin B, 2023, 13(2):662-677
S1688	Betamethasone Dipropionate	Betamethasone Dipropionate (SCH 11460) is a glucocorticoid steroid with anti-inflammatory and immunosuppressive abilities.	J Nanobiotechnology, 2024, 22(1):706
S6608	AL082D06	AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins.	Int J Mol Sci, 2023, 24(14)11700
S5486	Fluorometholone	Fluorometholone (Oxylone) is a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. It is usually used as eye drops in the treatment of allergic and inflammatory conditions of the eye.	Drug Test Anal, 2020, 10.1002/dta.2917
S1689	Meprednisone	Meprednisone (NSC 527579, SCH 4358) is a glucocorticoid and a methylated derivative of prednisone.
S1690	Betamethasone Valerate	Betamethasone Valerate is a moderately potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.
S2608	Fluocinonide	Fluocinonide (Vanos, nsc 101791) is a potent glucocorticoid steroid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema.
S3078	Beclomethasone dipropionate	Beclomethasone dipropionate(Beclovent,Beconase,Vancenase) is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.
S3617	(20S)-Protopanaxatriol	(20S)-Protopanaxatriol (g-PPT, 20(S)-APPT), a neuroprotective metabolite of ginsenoside, protopanaxatriol (g-PPT), is a functional ligand for both GR and ERbeta and could modulate endothelial cell functions through the Glucocorticoid Receptor (GR) and Estrogen/progestogen Receptor (ER).
S5973	Methylprednisolone Acetate	Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. Methylprednisolone activates ACE2 and reduces IL-6 levels, thus improves severe or critical COVID-19. Methylprednisolone markedly reduces autophagy and apoptosis.
S4228	Fluorometholone Acetate	Fluorometholone Acetate (NSC 47438, Oxylone acetate) is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.
E4918	BecloMethasone	BecloMethasone (Beclometasone) is a prototype agonist of Glucocorticoid Receptor. BecloMethasone and its derivatives display higher binding affinity to Glucocorticoid Receptors in rat liver, thymus, and hypophysis.
S4775	Cortodoxone	Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.
S2606	Mifepristone (RU-486)	Mifepristone is a remarkably active antagonist of progesterone receptor and glucocorticoid receptor with IC50 of 0.2 nM and 2.6 nM, respectively. Mifepristone promotes cell autophagy and apoptosis, decreases Bcl-2 level and increases Beclin1 level, accompanied by weakened interaction between Bcl-2 and Beclin1.Mifepristone (RU486) can be used to induce animal models of Spontaneous Abortion.	Pharmacol Res, 2025, 215:107696 Cell Death Dis, 2025, 16(1):237 J Virol, 2025, 99(2):e0147224
S4028	Dexamethasone Sodium Phosphate	Dexamethasone (Dexamethasone 21-phosphate disodium salt) is a potent synthetic member of the glucocorticoid class of steroid drugs, and an interleukin receptor modulator that has anti-inflammatory and immunosuppressant effects.	Proc Natl Acad Sci U S A, 2025, 122(12):e2426107122 J Tradit Chin Med, 2025, 45(4):739-746 Cancer Cell, 2024, 42(9):1507-1527.e11
E0177	Hydrocortisone sodium succinate	Hydrocortisone sodium succinate (Hydrocortisone 21-hemisuccinate sodium salt) has significant inhibitory effects on the IL-6 bioactivity with IC50 of 6.7 µM. This compound can bind to Glucocorticoid Receptor, initiating the transcription of anti-inflammatory and immunosuppressive mediators.